International Journal of Public Health and Epidemiology

Abstract: Previously, we investigated the induction effect of LRP16 expression by estrogen (E2) and established feed-forward mechanism that activated ERa transactivation in estrogen-dependent epithelial cancer cells. LRP16 is required for ERa signaling transduction by functioning as an ERa coactivator. In this study, we demonstrated that LRP16 expression was up-regulated in E2-responsive BG-1 ovarian cancer cells, but was down-regulated in estrogen-resistant SKOV3 ovarian cancer cells. Pure estrogen antagonist ICI 182 780 di…

Abstract: The hepatoprotective and some haematological effects of Allium sativum (Garlic) and vitamin C were studied on experimental rats that were exposed to lead (Pb) for one week. Twenty – four female Wistar rats were divided into four groups of six rats per group. Rats in group A were kept as the control. Rats in groups B, C and D were exposed to 100 µmol/kg body weight of lead acetate intraperitoneally for seven days. Garlic diet (200 g minced garlic/kg diet) and vitamin C (500 mg/kg body weight) were given to rats in g…

Abstract: A study to investigate the susceptibility pattern of Staphylococcus aureus to conventional antibiotics being frequently prescribed in Ile-Ife, South Western Nigeria was carried out. One hundred and seven samples from various clinical samples were collected from Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. The isolates of S. aureus were characterized and identified using standard microbiological techniques. The isolates harvested were subjected to in-vitro antibiotic susceptibility tests…

Abstract: This study determined the susceptibility pattern and multiple antibiotic resistance (MAR) index of 92 Pseudomonas aeruginosa strains from clinical samples comprising mainly urine (51.1%) and wounds (41.3%) obtained from the surgical units of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria; over a 24-month period. The strains were susceptible to imipenem (94.6%), ciprofloxacin (90.2%), amikacin (89.1%) and ceftazidime (78.3%) but resistant to ofloxacin (82.6%), perfloxacin (58.7%) and gentamicin (35.8%). A…

Abstract: Hepatocellular carcinoma is the fifth most common cancer in the world. Its incidence is increasing worldwide ranging between 3 and 9% annually. The aim of this study was to see the pattern of clinical presentation, identify the possible risk factors and the clinical outcome among HCC patients presenting at our health facility. The case records of all patients with histopathological diagnosis of HCC within the study period June 2003-May 2008 were scrutinized. Demographic, clinical presentation, investigations, risk…

Abstract: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease in diabetic patients. The aim of this study was to evaluate effects of metformin and folic acid on plasma homocysteine level in diabetic patients. In this clinical trial 47 new cases of type 2 diabetes were randomized to two groups. We treated patients in trial group with metformin and 1 mg folic acid, whereas patients in control group treated with metformin and placebo for 16 weeks. There was no significant difference in plasma hom…

Abstract: Granulomatous inflammation is considered to be an immune mechanism against infections or certain non-neoplastic conditions. Rarely granuloma formation may be noted in neoplastic disorders also. However a granulomatous response in the lymph nodes draining cancers is unusual. Such granulomas may sometimes show tumour cells in their centre. The exact cause of this phenomenon is not known but an immunologic reaction to tumour antigens has been suggested. A close scrutiny of such granuloma is necessary to avoid under di…

Abstract: In Burkina Faso, the prevalence of HBs antigen is estimated at 9.1%. We aimed to describe the therapeutic and evolutionary aspects of chronic HBeAg-negative viral hepatitis B outpatients at the University Hospital Yalgado Ouédraogo. Methods: It was a cross-sectional descriptive study including 325 participants with a retrospective data collection from January 2004 to April 2016. Results: The mean age was 38.7 years and the sex ratio, 1.5. The mean concentration of HBsAg and HBV Viral load was 7861.6 IU/mL and 32 23…